Answer: C. Within 48 hours of making an oral report.
Explanation: The LDSS 2221A form, which is used for reporting suspected child abuse or maltreatment in New York State, must be filed within 48 hours of making an oral report to the New York Statewide Central Register of Child Abuse and Maltreatment (SCR). This requirement ensures that there is a written record following the initial oral report.